Identifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer
作者: John R. StevensJennifer S. HerrickRoger K. WolffMartha L. Slattery
作者单位: 1Utah State University
2University of Utah
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-017-3690-x
关键词: MicroRNAColorectal cancerEpigeneticsDifferential expression
原始语种摘要: microRNAs are small non-protein-coding RNA molecules that regulate gene expression, and have a potential epigenetic role in disease progression and survival of colorectal cancer. In terms of tumor-normal expression differences, many microRNAs exhibit evidence of being up-regulated in some subjects but down-regulated in others, or are dysregulated only for a subset of the population. We present and implement an approach to identify factors (lifestyle, tumor molecular phenotype, and survival-related) that are associated with the direction and/or significance of these microRNAs’ tumor-normal expression differences in colorectal cancer.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • colorectal 结肠直肠的
  • expression 表示
  • normal 法线
  • cancer 癌症
  • associated 相关的
  • significance 显著性
  • tumor 肿胀
  • survival 生存
  • regulated 规定
  • epigenetic 后成的