An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia
作者: Kerri-Ann NortonTravis WallaceNiranjan B. PandeyAleksander S. Popel
作者单位: 1School of Medicine, Johns Hopkins University
刊名: BMC Systems Biology, 2017, Vol.11 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12918-017-0445-x
关键词: Systems biologyComputational modelBreast cancerTumor heterogeneity
原始语种摘要: Triple-negative breast cancer lacks estrogen, progesterone, and HER2 receptors and is thus not possible to treat with targeted therapies for these receptors. Therefore, a greater understanding of triple-negative breast cancer is necessary for the treatment of this cancer type. In previous work from our laboratory, we found that chemokine ligand-receptor CCL5-CCR5 axis is important for the metastasis of human triple-negative breast cancer cell MDA-MB-231 to the lymph nodes and lungs, in a mouse xenograft model. We collected relevant experimental data from our and other laboratories for numbers of cancer stem cells, numbers of CCR5+ cells, and cell migration rates for different breast cancer cell lines and different experimental conditions.
全文获取路径: Springer Nature  (合作)
影响因子:2.982 (2012)

  • breast 胸部
  • cancer 癌症
  • interplay 互相作用
  • triple 三重的
  • CCR Carriage Control Register
  • receptor 接受体
  • cells 麻风细胞
  • expression 表示
  • estrogen 雌激素
  • progesterone 孕酮