Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer
作者: Li LiWei WangHong PanGe MaXinyi ShiHui XieXiaoan LiuQiang DingWenbin ZhouShui Wang
作者单位: 1Nanjing Medical University
刊名: Journal of Translational Medicine, 2017, Vol.15 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12967-017-1124-9
关键词: Microwave ablationOK-432Breast cancerImmunotherapyT cell
英文摘要: Minimally invasive therapies, such as microwave ablation (MWA), are widely used for the treatment of solid tumors. Previous studies suggest that MWA is feasible for the treatment of small breast cancer, and thermal ablation may induce adaptive antitumor immunity. However, the induced immune responses are mostly weak, and the immunomodulation effects of MWA in breast cancer are unclear. Immunostimulant OK-432 can induce tumor-specific T-cell responses and may augment the immunity induced by MWA.
原始语种摘要: Minimally invasive therapies, such as microwave ablation (MWA), are widely used for the treatment of solid tumors. Previous studies suggest that MWA is feasible for the treatment of small breast cancer, and thermal ablation may induce adaptive antitumor immunity. However, the induced immune responses are mostly weak, and the immunomodulation effects of MWA in breast cancer are unclear. Immunostimulant OK-432 can induce tumor-specific T-cell responses and may augment the immunity induced by MWA.
全文获取路径: Springer Nature  (合作)
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影响因子:3.459 (2012)

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关键词翻译
关键词翻译
  • ablation 剥蚀
  • antitumor 抗癌的
  • breast 胸部
  • immunity 免疫
  • combined 组合
  • cancer 癌症
  • murine 鼠灰色
  • response 响应
  • induced 感应的
  • invasive 侵入的