Phosphorylation of astrocytic connexin43 by ERK1/2 impairs blood–brain barrier in acute cerebral ischemia
作者: Wei ChenJiugeng FengWusong Tong
作者单位: 1The People’s Hospital of Pu Dong New Area
2The First Affiliated Hospital of NanChang University
刊名: Cell & Bioscience, 2017, Vol.7 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13578-017-0170-6
关键词: Connexin43ERKPhosphorylationBlood–brain barrierIschemia
原始语种摘要: Connexins are a family of transmembrane proteins that form gap junctions, which are important for diffusion of cytosolic factors such as ions and second messenger signaling molecules. Our previous study has shown that Connexin40 (Cx40), one dominant connexin expressed in brain, was involved in brain injury. In this study, Cx43, another dominant connexin in brain, was investigated. Using bilateral common carotid artery occlusion-induced ischemia rat model, we tested the expression and phosphorylation level of Cx43 as well as heteromeric Cx40/Cx43 complex formation in brain after ischemia induction. We screened total 16 kinase inhibitors to identify the kinase for Cx43 phosphorylation and confirmed the result using siRNA targeting the specific kinase. Finally, we explored the role of the...
全文获取路径: Springer Nature  (合作)
影响因子:3 (2012)

  • barrier 堡坝
  • brain 
  • connexin 连接蛋白
  • ischemia 局部贫血
  • total 总和
  • level 水准
  • second 
  • previous 先前的
  • kinase 激酶
  • dominant 优势的