Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939
作者: Jun YangYan LiuBing WangHongzhen LanYing LiuFei ChenJu ZhangJian Luo
作者单位: 1Huazhong University of Science and Technology
2Beijing Institute of Genomics, Chinese Academy of Sciences
3Chinese Academy of Sciences
刊名: BMC Molecular Biology, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12867-017-0100-5
关键词: SumoylationP27kip1RanBP2Cholangiocarcinoma
原始语种摘要: Cholangiocarcinoma is one of the deadly disease with poor 5-year survival and poor response to conventional therapies. Previously, we found that p27kip1 nuclear-cytoplasmic translocation confers proliferation potential to cholangiocarcinoma cell line QBC939 and this process is mediated by crm-1. However, no other post-transcriptional regulation was found in this process including sumoylation in cholangiocarcinoma.
全文获取路径: Springer Nature  (合作)
影响因子:2.796 (2012)

  • deadly 致死
  • cancer 癌症
  • potential 
  • survival 生存
  • translocation 移位
  • found 创立
  • including 包括(气导)包括……在内包括…在内
  • growth 生长
  • process 过程
  • cytoplasmic 细胞质的