Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer
作者: Zhenbing LvJinlai WeiWenxian YouRong WangJingkun ShangYongfu XiongHua YangXuanhua YangZhongxue Fu
作者单位: 1The First Affiliated Hospital, Chongqing Medical University
2Nanchong Central Hospital
3The Second Clinical School of North Sichuan Medical College
刊名: Journal of Translational Medicine, 2017, Vol.15 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12967-017-1357-7
关键词: Colorectal cancerC-MycMiR-200b-3pPRDX2Chemotherapeutic resistanceMetastasis
英文摘要: Metastasis is a major threat to colorectal cancer (CRC) patients. We have reported that peroxiredoxin-2 (PRDX2) is associated with CRC invasion and metastasis. However, the mechanisms regulating PRDX2 expression remain unclear. We investigate whether microRNAs (miRNAs) regulate PRDX2 expression in CRC progression.
原始语种摘要: Metastasis is a major threat to colorectal cancer (CRC) patients. We have reported that peroxiredoxin-2 (PRDX2) is associated with CRC invasion and metastasis. However, the mechanisms regulating PRDX2 expression remain unclear. We investigate whether microRNAs (miRNAs) regulate PRDX2 expression in CRC progression.
全文获取路径: Springer Nature  (合作)
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影响因子:3.459 (2012)

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关键词翻译
关键词翻译
  • colorectal 结肠直肠的
  • metastasis 同质蜕变
  • regulatory 控制的
  • cancer 癌症
  • tumor 肿胀
  • regulate 控制
  • unclear 不清楚的
  • threat 威胁
  • investigate 
  • invasion 侵入