Increased sensitivity of NS1 ELISA by heat dissociation in acute dengue 4 cases
作者: Sibelle Nogueira BuonoraFlavia Barreto dos SantosRegina Paiva DaumasSonia Regina Lambert PassosManoela Heringer da SilvaMonique Rocha de LimaRita Maria Ribeiro Nogueira
作者单位: 1Laboratory of Clinical Epidemiology, Oswaldo Cruz Foundation
2Flavivirus Laboratory, Oswaldo Cruz Foundation
3National School of Public Health, Oswaldo Cruz Foundation, Rua Leopoldo Bulhões
刊名: BMC Infectious Diseases, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12879-017-2306-z
关键词: NS1 ELISAAccuracyDengue diagnosisImmune complex dissociationDENV-4
原始语种摘要: Dengue is an acute febrile illness considered the major arboviral disease in terms of morbidity, mortality, economic impact and dissemination worldwide. Brazil accounts for the highest notification rate, with circulation of all four dengue serotypes. The NS1 antigen is a dengue highly conserved specific soluble glycoprotein essential for viral replication and viability that can be detected 0 to 18 days from the onset of fever (peak first 3 days). It induces a strong humoral response and is known as a complement-fixing antigen. Lower NS1 test sensitivity occurs in secondary dengue infections probably due to immune complex formation impairing antigen detection by ELISA.
全文获取路径: Springer Nature  (合作)
影响因子:3.025 (2012)

  • dengue 登革热
  • ELISA 酶联免疫吸收分析
  • acute 急尖的
  • sensitivity 灵敏度
  • dissociation 解离
  • humoral 体液的
  • essential 本质的
  • antigen 抗原
  • immune 免疫的
  • glycoprotein 糖蛋白