Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1<sup>G93A</sup> Mouse Model of Amyotrophic Lateral Sclerosis
作者: Savina ApolloniPaola FabbrizioChiara ParisiSusanna AmadioCinzia Volonté
作者单位: 1CNR
2Santa Lucia Foundation, IRCCS,
刊名: Molecular Neurobiology, 2016, Vol.53 (1), pp.518-531
来源数据库: Springer Nature Journal
DOI: 10.1007/s12035-014-9019-8
关键词: Histamine H1 receptorMicrogliaMotor neuronP2X7M1/M2 phenotype
英文摘要: Abstract(#br)Mutations in the Cu2+/Zn2+ superoxide dismutase 1 (SOD1) gene underlie 14–23 % of familial and 1–7 % of sporadic cases of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease characterized by a specific loss of motor neurons in the brain and spinal cord. Neuroinflammation and oxidative stress are emerging as key players in the pathogenesis of ALS, thus justifying the interest in glial cells and particularly microglia, in addition to motor neurons, as novel therapeutic approaches against ALS. Recently, histamine was proven to participate in the pathogenesis of neuroinflammatory and neurodegenerative diseases, and particularly, microglia was shown to be sensitive to the histamine challenge mainly through histamine H1 receptors....
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影响因子:5.471 (2012)

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