Poly( β -cyclodextrin)-mediated polylactide-cholesterol stereocomplex micelles for controlled drug delivery
作者: Xiang-ru FengJian-xun DingRuxandra GrefXue-si Chen
作者单位: 1Chinese Academy of Sciences
2Université Paris Saclay
刊名: Chinese Journal of Polymer Science, 2017, Vol.35 (6), pp.693-699
来源数据库: Springer Nature Journal
DOI: 10.1007/s10118-017-1932-7
关键词: PolylactideStereocomplex micellePoly( β -cyclodextrin)Host-guest interactionControlled drug delivery
英文摘要: A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG- b -PLLA/PDLA-CHOL) and poly( β -cyclodextrin) (PCD) with the molar ratios of CHOL/ β -CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/ β -CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential...
原始语种摘要: A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG- b -PLLA/PDLA-CHOL) and poly( β -cyclodextrin) (PCD) with the molar ratios of CHOL/ β -CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/ β -CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential...
全文获取路径: Springer Nature  (合作)
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影响因子:1.27 (2012)

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关键词翻译
关键词翻译
  • cyclodextrin 环糊精
  • polylactide 聚交酯
  • micelle 胶束
  • interaction 相互酌
  • cholesterol 胆甾醇
  • guest 客户
  • possessed 占有的
  • armed 武装的
  • molar 克分子的
  • glycol 甘醇