A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models
作者: Domenico BrittiRosalia CrupiDaniela ImpellizzeriEnrico GugliandoloRoberta FuscoCarlo SchievanoValeria Maria MorittuMaurizio EvangelistaRosanna Di PaolaSalvatore Cuzzocrea
作者单位: 1Campus S. Venuta, Germaneto
2University of Messina
3Innovative Statistical Research SRL
4Catholic University of Sacred Heart
5University of Manchester
刊名: BMC Veterinary Research, 2017, Vol.13 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12917-017-1151-z
关键词: OsteoarthritisDisease modelsPainInflammationDrug combinationsPalmitoylethanolamideQuercetinCo-ultra micronizationN-acylethanolamines
英文摘要: Osteoarthritis (OA) is a common progressive joint disease in dogs and cats. The goal of OA treatment is to reduce inflammation, minimize pain, and maintain joint function. Currently, non-steroidal anti-inflammatory drugs (e.g., meloxicam) are the cornerstone of treatment for OA pain, but side effects with long-term use pose important challenges to veterinary practitioners when dealing with OA pain. Palmitoylethanolamide (PEA) is a naturally-occurring fatty acid amide, locally produced on demand by tissues in response to stress. PEA endogenous levels change during inflammatory and painful conditions, including OA, i.e., they are typically increased during acute conditions and decreased in chronic inflammation. Systemic treatment with PEA has anti-inflammatory and pain-relieving effects in...
原始语种摘要: Osteoarthritis (OA) is a common progressive joint disease in dogs and cats. The goal of OA treatment is to reduce inflammation, minimize pain, and maintain joint function. Currently, non-steroidal anti-inflammatory drugs (e.g., meloxicam) are the cornerstone of treatment for OA pain, but side effects with long-term use pose important challenges to veterinary practitioners when dealing with OA pain. Palmitoylethanolamide (PEA) is a naturally-occurring fatty acid amide, locally produced on demand by tissues in response to stress. PEA endogenous levels change during inflammatory and painful conditions, including OA, i.e., they are typically increased during acute conditions and decreased in chronic inflammation. Systemic treatment with PEA has anti-inflammatory and pain-relieving effects in...
全文获取路径: Springer Nature  (合作)
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影响因子:1.861 (2012)

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关键词翻译
关键词翻译
  • inflammation 炎症
  • inflammatory 激怒的
  • quercetin 槲皮苷
  • micronization 微分化
  • treatment 处理
  • novel 长篇小说
  • formulation 配方
  • increased 增加
  • carrageenan 卡拉胶
  • chronic 延续很长的