Mucosa-associated microbiota signature in colorectal cancer
作者: R. GaoC. KongL. HuangH. LiX. QuZ. LiuP. LanJ. WangH. Qin
作者单位: 1Shanghai Tenth People’s Hospital Affiliated to Tongji University School of Medicine
2Tongji University School of Medicine
3Sun Yat-sen University
刊名: European Journal of Clinical Microbiology & Infectious Diseases, 2017, Vol.36 (11), pp.2073-2083
来源数据库: Springer Nature Journal
DOI: 10.1007/s10096-017-3026-4
英文摘要: The aim of this study was to explore the gut microbiota profiles of colorectal cancer (CRC) patients and to examine the relationship between gut microbiota and other key molecular factors involved in CRC tumorigenesis. In this study, a 16S rDNA sequencing platform was used to identify possible differences in the microbiota signature between CRC and adjacent normal mucosal tissue. Differences in the microbiota composition in different anatomical colorectal tumor sites and their potential association with KRAS mutation were also explored. In this study, the number of Firmicutes and Actinobacteria decreased, while the number of Fusobacteria increased in the gut of CRC patients. In addition, at the genus level, Fusobacterium was identified as the key contributor to CRC tumorigenesis. In...
原始语种摘要: The aim of this study was to explore the gut microbiota profiles of colorectal cancer (CRC) patients and to examine the relationship between gut microbiota and other key molecular factors involved in CRC tumorigenesis. In this study, a 16S rDNA sequencing platform was used to identify possible differences in the microbiota signature between CRC and adjacent normal mucosal tissue. Differences in the microbiota composition in different anatomical colorectal tumor sites and their potential association with KRAS mutation were also explored. In this study, the number of Firmicutes and Actinobacteria decreased, while the number of Fusobacteria increased in the gut of CRC patients. In addition, at the genus level, Fusobacterium was identified as the key contributor to CRC tumorigenesis. In...
全文获取路径: Springer Nature  (合作)
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关键词翻译
关键词翻译
  • microbiota 微生物区系
  • associated 相关的
  • colorectal 结肠直肠的
  • signature 签名
  • mucosal 粘膜的
  • cancer 癌症
  • tumorigenesis 瘤形成
  • anatomical 解剖的
  • descending 
  • platform 台地