Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas
作者: Sharmeen ChaganiRong WangEvan L. CarpenterChristiane V. LöhrGitali Ganguli-IndraArup K. Indra
作者单位: 1Molecular and Cellular Biology Program, OSU
2Department of Pharmaceutical Sciences, College of Pharmacy
3Linus Pauling Institute, OSU
4College of Veterinary Medicine, Oregon State University
5Oregon Health & Science University (OHSU)
6Department of Dermatology, OHSU
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-017-3714-6
关键词: KeratinocytesMelanocytesAcute UVBRetinoid-X-receptor α (RXRα)Malignant melanomaTrigenicSpontaneous melanomaNRASQ61KCDK4R24C/R24CMicroenvironment
英文摘要: Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment. Keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) has a protective role against melanomagenesis and is involved in the regulation of keratinocyte and melanocyte homeostasis subsequent acute ultraviolet (UV) irradiation.
原始语种摘要: Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment. Keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) has a protective role against melanomagenesis and is involved in the regulation of keratinocyte and melanocyte homeostasis subsequent acute ultraviolet (UV) irradiation.
全文获取路径: Springer Nature  (合作)
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影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • neonatal 新生儿的
  • oncogenic 致癌的
  • malignant 恶性的
  • melanoma 黑瘤
  • metastatic 新陈代谢的
  • induced 感应的
  • spontaneous 自发的
  • acute 急尖的
  • keratinocyte 角化细胞
  • receptor 接受体