Dual Functional MicroRNA-186-5p Targets both FGF2 and RelA to Suppress Tumorigenesis of Glioblastoma Multiforme
作者: Fachen WangHui JiangShanjun WangBing Chen
作者单位: 1Yidu Central Hospital of Weifang
2Qingzhou Hospital of Traditional Chinese Medicine
3The Affiliated Hospital of Qingdao University
刊名: Cellular and Molecular Neurobiology, 2017, Vol.37 (8), pp.1433-1442
来源数据库: Springer Nature Journal
DOI: 10.1007/s10571-017-0474-4
关键词: Glioblastoma multiforme (GBM)MicroRNAs (miRs)Fibroblast growth factor (FGF)-2Tumorigenesis
原始语种摘要: Glioblastoma multiforme (GBM) is one of the most malignant cancers. MicroRNAs (miRs) were reported to play important roles in GBM recently. However, the role of a novel miR-186-5p in GBM tumorigenesis is still elusive. Using bioinformatics, miR-186-5p was identified as potential regulators of both fibroblast growth factor (FGF)-2 and NF-κB subunit RelA. Luciferase reporter assay was used to confirm the direct recognition FGF2 and RelA mRNAs by miR-186-5p. Invasion and migration assays were employed to study the effect of miR-186-5p on GBM cell growth in vitro. Xenograft tumor animal model was established to elucidate the in vivo function of miR-186-5p. MiR-186-5p directly targeted mRNAs of both FGF2 and RelA, and repressed their expressions. Invasive and migratory abilities of GBM cells...
全文获取路径: Springer Nature  (合作)
影响因子:2.293 (2012)

  • FGF 成纤维细胞生长因子
  • bioinformatics 生物信息学
  • growth 生长
  • novel 长篇小说
  • reporter 报告生成程序
  • potentially 可能地
  • targeted 对准目标的
  • tumorigenesis 瘤形成
  • factor 因素
  • targeting 导向目标