Cripto-1 acts as a functional marker of cancer stem-like cells and predicts prognosis of the patients in esophageal squamous cell carcinoma
作者: Qiang LiuXiang CuiXi YuBai-Shi-Jiao BianFeng QianXu-gang HuCheng-dong JiLang YangYong RenWei CuiXia ZhangPeng ZhangJi Ming WangYou-hong CuiXiu-wu Bian
作者单位: 1Southwest Hospital, Third Military Medical University
2Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute
刊名: Molecular Cancer, 2017, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12943-017-0650-7
关键词: Cripto-1Esophageal squamous cell carcinomaCancer stem-like cellsMetastasisPrognosis
原始语种摘要: Esophageal squamous cell carcinoma (ESCC) is highly malignant with highly invasive and metastatic capabilities and poor prognosis. It is believed that the ESCC cancer stem-like cells (ECSLCs) are critical for tumorigenicity, invasion and metastasis of ESCC. However, the properties of ECSLCs vary with different markers used in isolation, so that new and more effective markers of ECSLCs need to be identified. This study aimed to estimate the potentiality of Cripto-1 (CR-1) as an ECSLC surface marker and investigate the clinical significance of CR-1 expression in ESCC.
全文获取路径: Springer Nature  (合作)
影响因子:5.134 (2012)

  • squamous 具鳞的
  • prognosis 预报
  • carcinoma 癌症
  • esophageal 食管的
  • cells 麻风细胞
  • marker 标试器
  • cancer 癌症
  • metastasis 同质蜕变
  • metastatic 新陈代谢的
  • invasion 侵入