A novel interaction between kinase activities in regulation of cilia formation
作者: Nicole DeVaulKaterina KoloustroubisRong WangAnn O. Sperry
作者单位: 1Laboratory of Biochemistry and Genetics, National Institute of Diabetics and Digestive and Kidney Diseases, National Institutes of Health
2Anatomy and Cell Biology, East Carolina University, Brody School of Medicine
刊名: BMC Cell Biology, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12860-017-0149-5
关键词: CiliaAurANek2PP1PPP1R42
英文摘要: The primary cilium is an extension of the cell membrane that encloses a microtubule-based axoneme. Primary cilia are essential for transmission of environmental cues that determine cell fate. Disruption of primary cilia function is the molecular basis of numerous developmental disorders. Despite their biological importance, the mechanisms governing their assembly and disassembly are just beginning to be understood. Cilia growth and disassembly are essential events when cells exit and reenter into the cell cycle. The kinases never in mitosis-kinase 2 (Nek2) and Aurora A (AurA) act to depolymerize cilia when cells reenter the cell cycle from G0.
原始语种摘要: The primary cilium is an extension of the cell membrane that encloses a microtubule-based axoneme. Primary cilia are essential for transmission of environmental cues that determine cell fate. Disruption of primary cilia function is the molecular basis of numerous developmental disorders. Despite their biological importance, the mechanisms governing their assembly and disassembly are just beginning to be understood. Cilia growth and disassembly are essential events when cells exit and reenter into the cell cycle. The kinases never in mitosis-kinase 2 (Nek2) and Aurora A (AurA) act to depolymerize cilia when cells reenter the cell cycle from G0.
全文获取路径: Springer Nature  (合作)
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影响因子:2.808 (2012)

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关键词翻译
关键词翻译
  • kinase 激酶
  • cilia 睫毛
  • reenter 再接入
  • disassembly 分解
  • cilium 纤毛
  • regulation 
  • essential 本质的
  • understood 明白
  • depolymerize 解聚
  • importance 重要性