Lipopolysaccharide and Curcumin Co-Stimulation Potentiates Olfactory Ensheathing Cell Phagocytosis Via Enhancing Their Activation
作者: Ding-Jun HaoCuicui LiuLingling ZhangBo ChenQian ZhangRui ZhangJing AnJingjing ZhaoMingmei WuYi WangAlfred SimentalBaorong HeHao Yang
作者单位: 1Xi’an Jiaotong University College of Medicine
2The Fourth Military Medical University
3Loma Linda University Medical Center
4Xi’an
刊名: Neurotherapeutics, 2017, Vol.14 (2), pp.502-518
来源数据库: Springer Nature Journal
DOI: 10.1007/s13311-016-0485-8
关键词: Olfactory ensheathing cellsCell activationLipopolysaccharideCurcuminPhagocytosisNeuron growth
英文摘要: The gradual deterioration following central nervous system (CNS) injuries or neurodegenerative disorders is usually accompanied by infiltration of degenerated and apoptotic neural tissue debris. A rapid and efficient clearance of these deteriorated cell products is of pivotal importance in creating a permissive environment for regeneration of those damaged neurons. Our recent report revealed that the phagocytic activity of olfactory ensheathing cells (OECs) can make a substantial contribution to neuronal growth in such a hostile environment. However, little is known about how to further increase the ability of OECs in phagocytosing deleterious products. Here, we used an in vitro model of primary cells to investigate the effects of lipopolysaccharide (LPS) and curcumin (CCM) co-stimulation...
原始语种摘要: The gradual deterioration following central nervous system (CNS) injuries or neurodegenerative disorders is usually accompanied by infiltration of degenerated and apoptotic neural tissue debris. A rapid and efficient clearance of these deteriorated cell products is of pivotal importance in creating a permissive environment for regeneration of those damaged neurons. Our recent report revealed that the phagocytic activity of olfactory ensheathing cells (OECs) can make a substantial contribution to neuronal growth in such a hostile environment. However, little is known about how to further increase the ability of OECs in phagocytosing deleterious products. Here, we used an in vitro model of primary cells to investigate the effects of lipopolysaccharide (LPS) and curcumin (CCM) co-stimulation...
全文获取路径: Springer Nature  (合作)
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影响因子:5.904 (2012)

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关键词翻译
关键词翻译
  • phagocytic 吞噬细胞的
  • phagocytosis 噬菌
  • stimulation 激励
  • receptor 接受体
  • LPS Laboratory Peripheral System
  • permissive 许可的
  • effectively 有效地
  • CCM Charge Collection Mode
  • neuronal 二乙基溴乙酰胺
  • growth 生长