A strategy to build and validate a prognostic biomarker model based on RT-qPCR gene expression and clinical covariates
作者: Maud TournoudAudrey LarueMarie-Angelique CazalisFabienne VenetAlexandre PachotGuillaume MonneretAlain LepapeJean-Baptiste Veyrieras
作者单位: 1Bioinformatics Research Department
2Medical Diagnostic Discovery Department
3Laboratoire Commun de Recherche, Hospices Civils de Lyon
刊名: BMC Bioinformatics, 2015, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12859-015-0537-9
关键词: Prognostic survival modelRT-qPCR gene expression measurementCross-validationPerformance estimationModel optimism
英文摘要: Abstract(#br) Background(#br)Construction and validation of a prognostic model for survival data in the clinical domain is still an active field of research. Nevertheless there is no consensus on how to develop routine prognostic tests based on a combination of RT-qPCR biomarkers and clinical or demographic variables. In particular, the estimation of the model performance requires to properly account for the RT-qPCR experimental design.(#br) Results(#br)We present a strategy to build, select, and validate a prognostic model for survival data based on a combination of RT-qPCR biomarkers and clinical or demographic data and we provide an illustration on a real clinical dataset. First, we compare two cross-validation schemes: a classical outcome-stratified cross-validation scheme and an...
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影响因子:3.024 (2012)

  • validate 确认
  • build 建筑
  • strategy 战略
  • expression 表示
  • prognostic 预测的
  • biomarker 生物标志化合物
  • based 基于
  • model 模型
  • clinical 临床的