Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study
作者: Nicolino RupertoHermine I. BrunnerZbigniew ZuberNikolay TzaribachevDaniel J. KingsburyIvan FoeldvariGerd HorneffElzbieta SmolewskaRichard K. VeheAnasuya HazraRong WangCharles A. MebusChristine AlveyManisha LambaSriram KrishnaswamiThomas C. StockMin WangRicardo SuehiroAlberto MartiniDaniel J. Lovellfor the Pediatric Rheumatology International Trials Organization (PRINTO)the Pediatric Rheumatology Collaborative Study Group (PRCSG)
作者单位: 1Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO
2Cincinnati Children’s Hospital Medical Center, PRCSG
3St Louis Children’s Hospital ODS Rheumatology and Neurology
4Pediatric Rheumatology Research Institute
5Randall Children’s Hospital
6Hamburger Zentrum für Kinder- und Jugendrheumatologie
7Centre of General Pediatrics and Neonatology, Asklepios Klinik
8Medical University of Lodz
9University of Minnesota Masonic Children’s Hospital
10Pfizer Inc
11Istituto Giannina Gaslini, Direzione Scientifica
刊名: Pediatric Rheumatology, 2017, Vol.15 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12969-017-0212-y
关键词: Janus kinase inhibitorJuvenile idiopathic arthritisTofacitinibPediatricPharmacokineticsSafetyDosing
英文摘要: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in patients with JIA.
原始语种摘要: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in patients with JIA.
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:1.469 (2012)

×
关键词翻译
关键词翻译
  • arthritis 关节炎
  • polyarticular 多关节的
  • idiopathic 自发病的
  • profile 纵断图
  • course 航向
  • safety 安全
  • rheumatic 风湿病的
  • disability 回弹率
  • characterize 成为...的特性
  • juvenile 初生的