A comprehensive proteogenomic study of the human Brucella vaccine strain 104 M
作者: Xiaodong ZaiQiaoling YangKun LiuRuihua LiMengying QianTaoran ZhaoYaohui LiYing YinDayong DongLing FuShanhu LiJunjie XuWei Chen
作者单位: 1Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology
2Laboratory of Va
刊名: BMC Genomics, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12864-017-3800-9
关键词: Brucella abortus 104 MProteogenomicGenome reannotationVirulence factorProtective antigenMultichromosomal bacteria
英文摘要: Brucella spp. are Gram-negative, facultative intracellular pathogens that cause brucellosis in both humans and animals. The B. abortus vaccine strain 104 M is the only vaccine available in China for the prevention of brucellosis in humans. Although the B. abortus 104 M genome has been fully sequenced, the current genome annotations are not yet complete. In addition, the main mechanisms underpinning its residual toxicity and vaccine-induced immune protection have yet to be elucidated. Mapping the proteome of B. abortus 104 M will help to improve genome annotation quality, thereby facilitating a greater understanding of its biology.
原始语种摘要: Brucella spp. are Gram-negative, facultative intracellular pathogens that cause brucellosis in both humans and animals. The B. abortus vaccine strain 104 M is the only vaccine available in China for the prevention of brucellosis in humans. Although the B. abortus 104 M genome has been fully sequenced, the current genome annotations are not yet complete. In addition, the main mechanisms underpinning its residual toxicity and vaccine-induced immune protection have yet to be elucidated. Mapping the proteome of B. abortus 104 M will help to improve genome annotation quality, thereby facilitating a greater understanding of its biology.
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:4.397 (2012)

×
关键词翻译
关键词翻译
  • vaccine 菌苗
  • comprehensive 全面
  • human 人的
  • abortus 流产儿
  • genome 基因组
  • brucellosis 布鲁菌病
  • underpinning 加固基础
  • immune 免疫的
  • facultative 随意的
  • understanding 理解