Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF-κB/miR-155/PU.1 pathway
作者: Xue WuPing LiuHaijun ZhangYuan LiJumah Masoud Mohammad SalmaniFei WangKe YangRong FuZhewei ChenBaoan Chen
作者单位: 1Southeast University
2The Second Hospital of Nanjing Affiliated to Southeast University
3China Pharmaceutical University
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-017-3145-4
关键词: ApoptosisEBV infectionLymphomaNF-κBWogonin
原始语种摘要: Wogonin is an encouraging choice for clinical use owing to its potent anti-tumor and anti-inflammatory effects with the high safety profile. However, wogonin for targeted therapy of lymphoma was not well addressed. In this study, we focused on its anticancer effect alongside with the underlying mechanisms for targeted therapy in EBV-positive lymphoma. This will facilitate its introduction to clinical use, which is planned in the near future.
全文获取路径: Springer Nature  (合作)
影响因子:3.333 (2012)

  • lymphoma 淋巴瘤
  • targeted 对准目标的
  • therapeutic 治疗的
  • EBV Extended Binary Vectors
  • pathway 轨道
  • encouraging 鼓舞人心的
  • focused 聚焦的
  • potent 强大的
  • anticancer 抗癌的
  • underlying 下伏的