SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
作者: Zhibin YuYingnan SunXiaoling SheZeyou WangShuai ChenZhiyong DengYan ZhangQiang LiuQing LiuChunhua ZhaoPeiyao LiChanghong LiuJianbo FengHaijuan FuGuiyuan LiMinghua Wu
作者单位: 1Central South University
刊名: Journal of Hematology & Oncology, 2017, Vol.10 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13045-017-0483-2
关键词: SIX3AURKAAURKBTranscriptional repressor
英文摘要: SIX homeobox 3 (SIX3) is a member of the sine oculis homeobox transcription factor family. It plays a vital role in the nervous system development. Our previous study showed that the SIX3 gene is hypermethylated, and its expression is decreased in astrocytoma, but the role of SIX3 remains unknown.
原始语种摘要: SIX homeobox 3 (SIX3) is a member of the sine oculis homeobox transcription factor family. It plays a vital role in the nervous system development. Our previous study showed that the SIX3 gene is hypermethylated, and its expression is decreased in astrocytoma, but the role of SIX3 remains unknown.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:4.458 (2012)

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关键词翻译
关键词翻译
  • repressor 阻遏因子
  • astrocytoma 星形细胞瘤
  • homeobox 同源[异型]框
  • expression 表示
  • tumorigenesis 瘤形成
  • repression 制止
  • member 
  • family 
  • transcription 地名转写
  • remains 残渣