Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients’ survival
作者: Stamatios TheocharisConstantinos GiaginisParaskevi AlexandrouJose RodriguezJason TasoulasEugene DanasEfstratios PatsourisJerzy Klijanienko
作者单位: 1University of Athens
2Institut Curie
3University of the Aegean
刊名: Tumor Biology, 2016, Vol.37 (3), pp.3647-3656
来源数据库: Springer Nature Journal
DOI: 10.1007/s13277-015-4182-8
关键词: Mobile tongue squamous cell carcinomaCannabinoid receptorsClinicopathological parametersPrognosisImmunohistochemistry
原始语种摘要: Abstract(#br)Cannabinoid receptors (CB1R and CB2R) constitute essential members of the endocannabinoid system (ECS) which participates in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to assess the clinical significance of CB1R and CB2R protein expression in mobile tongue squamous cell carcinoma (SCC). CB1R and CB2R expression was assessed immunohistochemically on 28 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics and overall and disease-free patients’ survival. CB1R, CB2R, and concomitant CB1R/CB2R expression was significantly increased in older compared to younger mobile tongue SCC patients ( p = 0.0243, p = 0.0079, and p = 0.0366,...
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影响因子:2.518 (2012)

  • survival 生存
  • squamous 具鳞的
  • carcinoma 癌症
  • tongue 岩舌
  • cannabinoid 大麻的化学成分
  • expression 表示
  • parameters 参数
  • mobile 可动的