Altered gut microbiota in RA: implications for treatment
作者: Y. KangY. CaiX. ZhangX. KongJ. Su
作者单位: 1Kunming University of Science and Technology
刊名: Zeitschrift für Rheumatologie, 2017, Vol.76 (5), pp.451-457
来源数据库: Springer Nature Journal
DOI: 10.1007/s00393-016-0237-5
关键词: Gut microbiota dysbiosisAutoimmune disorderRheumatoid arthritisBiomarkers​Probiotic therapyDysbiose der DarmmikrobiotaAutoimmune StörungRheumatoide ArthritisBiomarkerProbiotische Therapie
英文摘要: Rheumatoid arthritis (RA) is an autoimmune disease with progressive joint disorder. The complex interplay of genetic and environmental influences is important for the development of the disease. A growing body of evidence has shed light on the association of dysbiosis of gut microbiota with RA. Certain gut microbial strains have been shown to inhibit or attenuate immune responses in RA experimental models, suggesting that specific species among intestinal commensal bacteria may play either a pathogenic or a protective role in the development of RA. Oral intake of probiotics/prebiotics can therefore represent a therapeutic approach for RA treatment. However, the relevant scientific work has only just begun, and the available data in this field remain limited. Fortunately, utilization of...
原始语种摘要: Rheumatoid arthritis (RA) is an autoimmune disease with progressive joint disorder. The complex interplay of genetic and environmental influences is important for the development of the disease. A growing body of evidence has shed light on the association of dysbiosis of gut microbiota with RA. Certain gut microbial strains have been shown to inhibit or attenuate immune responses in RA experimental models, suggesting that specific species among intestinal commensal bacteria may play either a pathogenic or a protective role in the development of RA. Oral intake of probiotics/prebiotics can therefore represent a therapeutic approach for RA treatment. However, the relevant scientific work has only just begun, and the available data in this field remain limited. Fortunately, utilization of...
全文获取路径: Springer Nature  (合作)
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影响因子:0.45 (2012)

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关键词翻译
关键词翻译
  • microbiota 微生物区系
  • commensal 同住者
  • arthritis 关节炎
  • treatment 处理
  • intestinal 肠的
  • disorder 无序
  • immune 免疫的
  • bacterial 细菌的
  • interplay 互相作用
  • development 开发