Loss of P2X7 receptor function dampens whole body energy expenditure and fatty acid oxidation
作者: Giacomo GiacovazzoSavina ApolloniRoberto Coccurello
作者单位: 1Institute of Cell Biology and Neurobiology (IBCN), National Research Council (C.N.R.)
2European Center for Brain Research (CERC)/Santa Lucia Foundation IRCCS
刊名: Purinergic Signalling, 2018, Vol.14 (3), pp.299-305
来源数据库: Springer Nature Journal
DOI: 10.1007/s11302-018-9610-y
关键词: Purinergic signalingP2X7 receptorEnergy metabolismEnergy expenditureFat acids oxidationObesity
英文摘要: Abstract(#br)The established role of ATP-responsive P2X7 receptor in inflammatory, neurodegenerative, and immune diseases is now expanding to include several aspects of metabolic dysregulation. Indeed, P2X7 receptors are involved in β cell function, insulin secretion, and liability to diabetes, and loss of P2X7 function may increase the risk of hepatic steatosis and disrupt adipogenesis. Recently, body weight gain, abnormal lipid accumulation, adipocyte hyperplasia, increased fat mass, and ectopic fat distribution have been found in P2X7 KO mice. Here, we hypothesized that such clinical picture of dysregulated lipid metabolism might be the result of altered in vivo energy metabolism. By indirect calorimetry, we assessed 24 h of energy expenditure (EE) and respiratory exchange ratio (RER)...
全文获取路径: Springer Nature  (合作)
影响因子:2.635 (2012)