Evaluation of biases present in the cohort multiple randomised controlled trial design: a simulation study
作者: Jane CandlishAlexander PateMatthew SperrinTjeerd van Staaon behalf of GetReal Work Package 2
作者单位: 1University of Manchester
2University of Sheffield
3Utrecht University
刊名: BMC Medical Research Methodology, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12874-017-0295-7
关键词: Trials within cohortsCohort multiple randomised controlled trialPragmatic trialInstrumental variable
原始语种摘要: The cohort multiple randomised controlled trial (cmRCT) design provides an opportunity to incorporate the benefits of randomisation within clinical practice; thus reducing costs, integrating electronic healthcare records, and improving external validity. This study aims to address a key concern of the cmRCT design: refusal to treatment is only present in the intervention arm, and this may lead to bias and reduce statistical power.
全文获取路径: Springer Nature  (合作)
影响因子:2.211 (2012)

  • design 设计
  • multiple 多次的
  • controlled 受控
  • trial 试验
  • opportunity 机会
  • variable 变量
  • cohort 伙伴
  • incorporate 加入
  • costs 费用
  • integrating 集成