Apocynin Alleviates Renal Ischemia/Reperfusion Injury Through Regulating the Level of Zinc and Metallothionen
作者: Bo HuYuhong WuFei TongJie LiuXiaohua ShenRuilin ShenGuangtao Xu
作者单位: 1Zhejiang Chinese Medical University
2Jiaxing University Medical College
刊名: Biological Trace Element Research, 2017, Vol.178 (1), pp.71-78
来源数据库: Springer Nature Journal
DOI: 10.1007/s12011-016-0904-z
关键词: ApocyninZincMetallothioneinInterleukinSuperoxide dismutaseRenal ischemia/reperfusion injury
英文摘要: The purpose of this research was to evaluate the protective effects of apocynin on renal ischemia/reperfusion (I/R) injury (RI/RI) in rats. Rats preconditioned with apocynin were subjected to renal I/R. Zinc levels in serum and renal tissues, blood urea nitrogen (BUN), and serum creatinine (Scr) were detected. We further measured the activity of superoxide dismutase (SOD); the content of malondialdehyde (MDA), IL-4, IL-6, IL-10, and TNF-α; and the expression of metallothionein (MT) in the renal tissues. Results indicated that the levels of MDA, IL-4, IL-6, IL-10, TNF-α, and MT in the kidney tissue and serum BUN and Scr levels in RI/RI group were significantly higher than those in sham-operated group, while the levels of serum Zn and kidney Zn and SOD were reduced in RI/RI group. Apocynin...
原始语种摘要: The purpose of this research was to evaluate the protective effects of apocynin on renal ischemia/reperfusion (I/R) injury (RI/RI) in rats. Rats preconditioned with apocynin were subjected to renal I/R. Zinc levels in serum and renal tissues, blood urea nitrogen (BUN), and serum creatinine (Scr) were detected. We further measured the activity of superoxide dismutase (SOD); the content of malondialdehyde (MDA), IL-4, IL-6, IL-10, and TNF-α; and the expression of metallothionein (MT) in the renal tissues. Results indicated that the levels of MDA, IL-4, IL-6, IL-10, TNF-α, and MT in the kidney tissue and serum BUN and Scr levels in RI/RI group were significantly higher than those in sham-operated group, while the levels of serum Zn and kidney Zn and SOD were reduced in RI/RI group. Apocynin...
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影响因子:1.307 (2012)

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关键词翻译
关键词翻译
  • apocynin 夹竹桃麻素
  • renal 肾的
  • dismutase 歧化酶
  • reperfusion 多次灌注液
  • serum 血清
  • superoxide 过氧化物
  • ischemia 局部贫血
  • SOD Superintendent Of Documents
  • against 反对
  • expression 表示