Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis
作者: Yan LiuHong XuYucong GengDingjie XuLijuan ZhangYi YangZhongqiu WeiBonan ZhangShifeng LiXuemin GaoRuimin WangXianghong ZhangDarrell BrannFang Yang
作者单位: 1Hebei Medical University
2North China University of Science and Technology
3Augusta University
刊名: Respiratory Research, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12931-017-0523-z
关键词: SilicosisMyofibroblastCAMPPKACREBSmad
英文摘要: Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by silica.
原始语种摘要: Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by silica.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:3.642 (2012)

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关键词翻译
关键词翻译
  • cAMP 环腺苷酸
  • silicosis 硅肺
  • PKA Public Key Algorithm
  • fibrosis 纤维化
  • myofibroblast 成肌纤维细胞
  • blocking 阻塞
  • pulmonary 肺的
  • fibrotic 纤维变性的
  • CBP Compressor Bleed Pressure
  • signaling 发信号