In silico pathway analysis and tissue specific cis -eQTL for colorectal cancer GWAS risk variants
作者: Lenora W. M. LooMathieu LemireLoïc Le Marchand
作者单位: 1University of Hawaii Cancer Center
2661 University Avenue
刊名: BMC Genomics, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12864-017-3750-2
关键词: Colorectal cancerEQTLRisk variantGene expression
原始语种摘要: Genome-wide association studies have identified 55 genetic variants associated with colorectal cancer risk to date. However, potential causal genes and pathways regulated by these risk variants remain to be characterized. Therefore, we performed gene ontology enrichment and pathway analyses to determine if there was an enrichment of genes in proximity to the colorectal cancer risk variants that could further elucidate the probable causal genes and pathways involved in colorectal cancer biology.
全文获取路径: Springer Nature  (合作)
影响因子:4.397 (2012)

  • colorectal 结肠直肠的
  • cancer 癌症
  • pathway 轨道
  • enrichment 富集
  • potential 
  • causal 因果
  • variant 变体
  • regulated 规定
  • expression 表示
  • proximity 邻近