Association of calcium sensing receptor polymorphisms at rs1801725 with circulating calcium in breast cancer patients
作者: Li WangSarrah E. WidatallaDiva S. WhalenJosiah OchiengAmos M. Sakwe
作者单位: 1Vanderbilt University
2Meharry Medical College
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-017-3502-3
关键词: Calcium-sensing receptorSingle nucleotide polymorphismCancer-induced hypercalcemiaBreast cancerGenome-wide association studies
英文摘要: Breast cancer (BC) patients with late-stage and/or rapidly growing tumors are prone to develop high serum calcium levels which have been shown to be associated with larger and aggressive breast tumors in post and premenopausal women respectively. Given the pivotal role of the calcium sensing receptor (CaSR) in calcium homeostasis, we evaluated whether polymorphisms of the CASR gene at rs1801725 and rs1801726 SNPs in exon 7, are associated with circulating calcium levels in African American and Caucasian control subjects and BC cases.
原始语种摘要: Breast cancer (BC) patients with late-stage and/or rapidly growing tumors are prone to develop high serum calcium levels which have been shown to be associated with larger and aggressive breast tumors in post and premenopausal women respectively. Given the pivotal role of the calcium sensing receptor (CaSR) in calcium homeostasis, we evaluated whether polymorphisms of the CASR gene at rs1801725 and rs1801726 SNPs in exon 7, are associated with circulating calcium levels in African American and Caucasian control subjects and BC cases.
全文获取路径: Springer Nature  (合作)
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影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • breast 胸部
  • receptor 接受体
  • calcium 
  • Association 美国公共卫生协会
  • premenopausal 绝经前期的
  • cancer 癌症
  • sensing 感觉
  • hypercalcemia 血钙过多
  • aggressive 侵蚀的
  • nucleotide 核苷酸