Bone marrow-derived mesenchymal stem cells induced by inflammatory cytokines produce angiogenetic factors and promote prostate cancer growth
作者: Ke-Qin YangYan LiuQing-Hua HuangNing MoQing-Yun ZhangQing-Gui MengJi-Wen Cheng
作者单位: 1Guiping People’s Hospital
2Affiliated Tumor Hospital of Guangxi Medical University
3The First Affiliated Hospital of Guangxi Medical University
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-017-3879-z
关键词: Prostate cancerMesenchymal stem cellsAngiogenesisHIF-1αNRF2InflammationPDGFVEGF
英文摘要: Prostate is susceptible to infection and pro-inflammatory agents in a man’s whole life. Chronic inflammation might play important roles in the development and progression of prostate cancer. Mesenchymal stem cells (MSCs) are often recruited to the tumor microenvironment due to local inflammation. We have asked whether stimulation of MSCs by pro-inflammatory cytokines could promote prostate tumor growth. The current study investigated the possible involvement of MSCs stimulated by pro-inflammatory cytokines in promotion and angiogenesis of prostate cancer through relative pathway in vitro and in vivo.
原始语种摘要: Prostate is susceptible to infection and pro-inflammatory agents in a man’s whole life. Chronic inflammation might play important roles in the development and progression of prostate cancer. Mesenchymal stem cells (MSCs) are often recruited to the tumor microenvironment due to local inflammation. We have asked whether stimulation of MSCs by pro-inflammatory cytokines could promote prostate tumor growth. The current study investigated the possible involvement of MSCs stimulated by pro-inflammatory cytokines in promotion and angiogenesis of prostate cancer through relative pathway in vitro and in vivo.
全文获取路径: Springer Nature  (合作)
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影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • cytokines 细胞浆移动
  • prostate 前列腺
  • mesenchymal 间叶细胞的
  • inflammatory 激怒的
  • cells 麻风细胞
  • promote 助长
  • induced 感应的
  • inflammation 炎症
  • cancer 癌症
  • marrow 骨髓