Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study
作者: Ivayla D. YozovaJudith HowardDiana HenkeDaniel DirkmannKatja N. Adamik
作者单位: 1Massey University
2Vetsuisse Faculty, University of Bern
3Essen University Hospital
刊名: BMC Veterinary Research, 2017, Vol.13 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12917-017-1108-2
关键词: Intracranial hypertensionOsmotherapyHypertonic salineMannitolHemostasisThromboelastometryPlatelet function
原始语种摘要: Hyperosmolar therapy with either mannitol or hypertonic saline (HTS) is commonly used in the treatment of intracranial hypertension (ICH). In vitro data indicate that both mannitol and HTS affect coagulation and platelet function in dogs. The aim of this study was to compare the effects of 20% mannitol and 7.2% HTS on whole blood coagulation using rotational thromboelastometry (ROTEM®) and platelet function using a platelet function analyzer (PFA®) in dogs with suspected ICH. Thirty client-owned dogs with suspected ICH needing osmotherapy were randomized to receive either 20% mannitol (5 ml/kg IV over 15 min) or 7.2% HTS (4 ml/kg IV over 5 min). ROTEM® (EXTEM® and FIBTEM® assays) and PFA® analyses (collagen/ADP cartridges) were performed before (T0), as well as 5...
全文获取路径: Springer Nature  (合作)
影响因子:1.861 (2012)

  • mannitol 甘露糖醇
  • hypertension 高血压
  • saline 盐的
  • intracranial 颅内的
  • coagulation 凝聚
  • whole 全部的
  • osmotherapy 渗透疗法
  • platelet 血小板
  • pilot 驾驶员
  • hypertonic 过度紧张的