Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells
作者: Haijian SunWeiwei CaiXu WangYanling LiuBao HouXuexue ZhuLiying Qiu
作者单位: 1Wuxi Medical School, Jiangnan University
2School of Pharmaceutical Science, Jiangnan University
刊名: BMC Complementary and Alternative Medicine, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12906-017-1635-1
关键词: COX-2INOSERKNFκBInflammationHypaphorine
英文摘要: Activation of macrophage is involved in many inflammation diseases. Lipopolysaccharide (LPS) is a powerful inflammatory signal contributing to monocytes/macrophages activation associated with increased proinflammatory cytokines expressions. We recently identified that vaccarin was expected to protect endothelial cells from injury. Hypaphorine was abundantly found in vaccaria semen. However, the potential roles and underlying mechanisms of vaccaria hypaphorine on macrophage inflammation have been poorly defined.
原始语种摘要: Activation of macrophage is involved in many inflammation diseases. Lipopolysaccharide (LPS) is a powerful inflammatory signal contributing to monocytes/macrophages activation associated with increased proinflammatory cytokines expressions. We recently identified that vaccarin was expected to protect endothelial cells from injury. Hypaphorine was abundantly found in vaccaria semen. However, the potential roles and underlying mechanisms of vaccaria hypaphorine on macrophage inflammation have been poorly defined.
全文获取路径: Springer Nature  (合作)
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影响因子:2.082 (2012)

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关键词翻译
关键词翻译
  • hypaphorine 色氨酸三甲基内盐
  • inflammation 炎症
  • cells 麻风细胞
  • macrophage 巨噬细胞
  • powerful 强大的
  • inactivation 失活
  • cytokines 细胞浆移动
  • protect 庇护
  • induced 感应的
  • poorly 贫乏地