In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer
作者: Anna TorresJoanna KozakAgnieszka KorolczukPaulina WdowiakEwa Domańska-GlonekRyszard MaciejewskiKamil Torres
作者单位: 1Medical University of Lublin
刊名: BMC Cancer, 2016, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-016-2867-z
关键词: miR-92aLNA-inhibitorEndometrial cancerMice xenograftProliferationIn vivo
英文摘要: Abstract(#br) Background(#br)Endometrial cancer is the most common cancer of the female reproductive tract.(#br)Based on our previous studies we speculated that miR-92a exhibited pro-oncogenic properties in endometrial cancer, and therefore its inhibition could be used as a therapeutic measure in this disease. Therefore in the present study we aimed to investigate both in vitro and in vivo if inhibition of miR-92a in endometrial cancer would limit cancer cells proliferation.(#br) Methods(#br)miR-92a expression was evaluated in four endometrial cancer cell lines using qPCR. Inhibition of miR-92a activity was obtained in endometrial cancer cell lines by a transient transfection of a custom designed Locked Nucleic Acid (LNA)-Inhibitor, developed to work both in vitro and in vivo. In vitro...
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影响因子:3.333 (2012)

  • endometrial 子宫内膜的
  • LNA Low-Noise Amplifier
  • against 反对
  • vitro 体外
  • activity 活度
  • cancer 癌症