Radiosynthesis of β-phenylethylamine derivatives for cardiac sympathetic nervous PET imaging
作者: Yulin HeXiaojun ZhangJian LiuJinming ZhangXuemei Wang
作者单位: 1Chinese PLA General Hospital
2The Affiliated Hospital of Inner Mongolia Medical University
刊名: Journal of Radioanalytical and Nuclear Chemistry, 2019, Vol.319 (3), pp.827-835
来源数据库: Springer Nature Journal
DOI: 10.1007/s10967-018-06405-5
关键词: Β-PhenylethylamineCarbon-11 labelingCardiac sympathetic nervousPositron imaging agent
英文摘要: β-Phenylethylamine is one of the core structure for synthesis of cardiac imaging agents. 11C-MDA is a β-phenylethylamine-based agent, which showed potential imaging performance. To further explore the potentials of the β-phenylethylamine derivatives, 11C-MPEA, 11C-m-MTyr and 11C-p-MTyr were synthesized. The three agents were stable in vitro. The radioactivity uptake of them in myocardium was similar to that in muscle. 11C-p-MTyr PET/CT imaging in New Zealand white rabbits showed a blurred left ventricular image along with a reduced radioactivity uptake. These results suggested the newly synthesized β-phenylethylamine derivatives, unlike 11C-MDA, may not be suitable as the cardiac PET imaging agents.
原始语种摘要: β-Phenylethylamine is one of the core structure for synthesis of cardiac imaging agents. 11C-MDA is a β-phenylethylamine-based agent, which showed potential imaging performance. To further explore the potentials of the β-phenylethylamine derivatives, 11C-MPEA, 11C-m-MTyr and 11C-p-MTyr were synthesized. The three agents were stable in vitro. The radioactivity uptake of them in myocardium was similar to that in muscle. 11C-p-MTyr PET/CT imaging in New Zealand white rabbits showed a blurred left ventricular image along with a reduced radioactivity uptake. These results suggested the newly synthesized β-phenylethylamine derivatives, unlike 11C-MDA, may not be suitable as the cardiac PET imaging agents.
全文获取路径: Springer Nature  (合作)
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关键词翻译
关键词翻译
  • imaging 图像形成
  • nervous 神经的
  • sympathetic 表示同情的
  • cardiac 贲门
  • derivatives 派生物
  • radioactivity 放射性
  • myocardium 心肌
  • PET PagE frame Table
  • blurred 弄污的
  • labeling 加标