Modulation of the balance of fatty acid production and secretion is crucial for enhancement of growth and productivity of the engineered mutant of the cyanobacterium Synechococcus elongatus
作者: Akihiro KatoKazuhide UseNobuyuki TakataniKazutaka IkedaMiyuki MatsuuraKouji KojimaMakiko AichiShin-ichi MaedaTatsuo Omata
作者单位: 1Nagoya University
2Japan Science and Technology Agency, CREST
3Keio University
4Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences
5Chubu University
刊名: Biotechnology for Biofuels, 2016, Vol.9 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13068-016-0506-1
关键词: CyanobacteriaBiofuel productionFree fatty acidsO-antigen
英文摘要: Abstract(#br) Background(#br)Among the three model cyanobacterial species that have been used for engineering a system for photosynthetic production of free fatty acids (FFAs), Synechococcus elongatus PCC7942 has been the least successful; the FFA-excreting mutants constructed from this strain could attain lower rates of FFA excretion and lower final FFA concentrations than the mutants constructed from Synechocystis sp. PCC6803 and Synechococcus sp. PCC7002. It has been suggested that S. elongatus PCC7942 cells suffer from toxicity of FFA, but the cause of the low productivity has remained to be determined.(#br) Results(#br)By modulating the expression level of the acyl–acyl carrier protein thioesterase and raising the light intensity during cultivation, FFA secretion rates comparable to...
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影响因子:5.552 (2012)

  • balance 平衡
  • growth 生长
  • enhancement 增强
  • Synechococcus synechococcus属
  • fatty 脂肪的
  • productivity 生产能力
  • crucial 有决定性的
  • production 生产
  • mutant 突变体
  • secretion 分泌