Identification of gene pairs through penalized regression subject to constraints
作者: Rex ShenLan LuoHui Jiang
作者单位: 1The Blake School
2University of Michigan
刊名: BMC Bioinformatics, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12859-017-1872-9
关键词: Gene pairBiomarkerPenalized regressionADMM
英文摘要: This article concerns the identification of gene pairs or combinations of gene pairs associated with biological phenotype or clinical outcome, allowing for building predictive models that are not only robust to normalization but also easily validated and measured by qPCR techniques. However, given a small number of biological samples yet a large number of genes, this problem suffers from the difficulty of high computational complexity and imposes challenges to the accuracy of identification statistically.
原始语种摘要: This article concerns the identification of gene pairs or combinations of gene pairs associated with biological phenotype or clinical outcome, allowing for building predictive models that are not only robust to normalization but also easily validated and measured by qPCR techniques. However, given a small number of biological samples yet a large number of genes, this problem suffers from the difficulty of high computational complexity and imposes challenges to the accuracy of identification statistically.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:3.024 (2012)

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关键词翻译
关键词翻译
  • constraints 系统规定参数
  • computational 计算的
  • normalization 正规化
  • regression 海退
  • subject 问题
  • article 冠词
  • robust 牢固的
  • predictive 预言
  • through 经过
  • complexity 错综性