Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives?
作者: Mattia Di NunzioVeronica ValliLidia Tomás-CobosTeresa Tomás-ChisbertLucía Murgui-BoschFrancesca DanesiAlessandra Bordoni
作者单位: 1University of Bologna
2Ainia Centro Tecnológico, Parque Tecnológico de Valencia
刊名: BMC Complementary and Alternative Medicine, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12906-017-1962-2
关键词: CytotoxicityDocosahexaenoic acidCyanidin-3- O -glucosideProtocatechuic acidPropionateHepG2 cells
英文摘要: Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is often used to select the most promising molecules to be studied in vivo . To avoid misleading results, concentration and chemical form, exposure time, and potential cytotoxicity of the tested bioactives should be carefully set prior to any other experiments.
原始语种摘要: Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is often used to select the most promising molecules to be studied in vivo . To avoid misleading results, concentration and chemical form, exposure time, and potential cytotoxicity of the tested bioactives should be carefully set prior to any other experiments.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:2.082 (2012)

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关键词翻译
关键词翻译
  • effects 海员自身物品
  • promising 前提
  • studied 学习
  • chemical 化学的
  • glucoside 糖甙
  • range 射程
  • cytotoxicity 细胞毒性
  • concentration 浓度
  • compounds 化合物
  • intervention