Role of nifedipine and hydrochlorothiazide in MAPK activation and vascular smooth muscle cell proliferation and apoptosis
作者: J. WangK. LiuH. WangZ. LiY. LiS. PingA. S. A. BardeesiY. GuoY. ZhouT. PeiL. DengP. ShengS. LiuC. Li
作者单位: 1Sun Yat-sen University
2the First Affiliated Hospital of Sun Yat-sen University
刊名: Herz, 2017, Vol.42 (6), pp.573-584
来源数据库: Springer Nature Journal
DOI: 10.1007/s00059-016-4489-2
关键词: StressMechanicalMuscleSmoothVascularNifedipineHydrochlorothiazideMAPK phosphorylationMechanische BelastungGlatter GefäßmuskelNifedipinHydrochlorothiazidMAPK-Phospholysierung
原始语种摘要: Once hypertension is established, increased mechanical stretch stress becomes a leading cause of vascular remodeling. Clinical antihypertension guidelines demonstrate that antihypertension drugs prevent vascular remodeling in hypertensive patients mainly by lowering blood pressure, suggesting an indirect way of reducing the effects of stretch stress (hypertension). Whether these drugs can directly block the effects of the stretch stress on vascular remodeling has not been reported to date. This study was designed to answer this question and explore the underlying mechanisms.
全文获取路径: Springer Nature  (合作)
影响因子:0.779 (2012)

  • vascular 维管的
  • nifedipine 硝苯啶
  • hypertension 高血压
  • stretch 伸长
  • muscle 肌肉
  • hypertensive 高血压的
  • smooth 平滑的
  • activation 活化
  • prevent 避免
  • proliferation 增生