Comparative analyses of genetic risk prediction methods reveal extreme diversity of genetic predisposition to nonalcoholic fatty liver disease (NAFLD) among ethnic populations of India
作者: ANKITA CHATTERJEEANALABHA BASUABHIJIT CHOWDHURYKAUSIK DASNEETA SARKAR-ROYPARTHA P. MAJUMDERPRIYADARSHI BASU
作者单位: 1National Institute of Biomedical Genomics, Netaji Subhas Sanatorium (T. B. Hospital)
2Institute of Post Graduate Medical Education and Research
3Biomedical Genomics Center, PG Polyclinic Building
刊名: Journal of Genetics, 2015, Vol.94 (1), pp.105-113
来源数据库: Springer Nature Journal
DOI: 10.1007/s12041-015-0494-0
关键词: nonalcoholic fatty liver diseaserisk modelethnicitysingle-nucleotide polymorphism
原始语种摘要: Abstract(#br)Nonalcoholic fatty liver disease (NAFLD) is a distinct pathologic condition characterized by a disease spectrum ranging from simple steatosis to steato-hepatitis, cirrhosis and hepatocellular carcinoma. Prevalence of NAFLD varies in different ethnic groups, ranging from 12% in Chinese to 45% in Hispanics. Among Indian populations, the diversity in prevalence is high, ranging from 9% in rural populations to 32% in urban populations, with geographic differences as well. Here, we wished to find out if this difference is reflected in their genetic makeup. To date, several candidate genes and a few genomewide association studies (GWAS) have been carried out, and many associations between single nucleotide polymorphisms (SNPs) and NAFLD have been observed. In this study, the risk...
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影响因子:0.876 (2012)

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关键词翻译
关键词翻译
  • extreme 极端的
  • prediction 预报
  • genetic 遗传的
  • predisposition 素质
  • fatty 脂肪的
  • ethnic 种族
  • reveal 显露
  • liver 
  • India 印度
  • among 在当中