An ELISA assay using a combination of recombinant proteins from multiple strains of Orientia tsutsugamushi offers an accurate diagnosis for scrub typhus
作者: Chien-Chung ChaoZhiwen ZhangTatyana BelinskayaWilawan ThipmontreeWiwit TantibhedyangkulSaowaluk SilpasakornEkkarat WongsawatYupin SuputtamongkolWei-Mei Ching
作者单位: 1Viral and Rickettsial Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center
2Uniformed Services University of the Health Sciences
3Maharat Nakhon Ratchasima Hospital
4Mahidol University
刊名: BMC Infectious Diseases, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12879-017-2512-8
关键词: Scrub typhusDiagnosisElisaRecombinant protein antigens
英文摘要: Scrub typhus (ST) is a disease caused by an obligate intracellular bacterium, Orientia tsutsugamushi , an organism that requires a BSL3 laboratory for propagation. The disease is hallmarked by an eschar at the site of the chigger bite, followed by the development of fever, malaise, myalgia, anorexia, and papulomacular rash. Indirect immunofluorescent assay (IFA) is the gold standard for scrub typhus diagnosis, however, the subjectivity of the assay, the need for a specialized laboratory and instruments has limited the wide use of the test in resource limited areas.
原始语种摘要: Scrub typhus (ST) is a disease caused by an obligate intracellular bacterium, Orientia tsutsugamushi , an organism that requires a BSL3 laboratory for propagation. The disease is hallmarked by an eschar at the site of the chigger bite, followed by the development of fever, malaise, myalgia, anorexia, and papulomacular rash. Indirect immunofluorescent assay (IFA) is the gold standard for scrub typhus diagnosis, however, the subjectivity of the assay, the need for a specialized laboratory and instruments has limited the wide use of the test in resource limited areas.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:3.025 (2012)

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关键词翻译
关键词翻译
  • tsutsugamushi 恙虫
  • typhus 斑疹伤寒
  • scrub 灌木丛
  • ELISA 酶联免疫吸收分析
  • recombinant 重组体
  • assay 试金
  • laboratory 实验室
  • eschar 
  • anorexia 食欲缺乏
  • chigger 恙螨