Exploring eukaryotic formate metabolisms to enhance microbial growth and lipid accumulation
作者: Zhiguo LiuTolutola OyetundeWhitney D. HollinsheadAnna HermannsYinjie J. TangWei LiaoYan Liu
作者单位: 1Michigan State University
2Washington University in St. Louis
3Heinrich Heine University
刊名: Biotechnology for Biofuels, 2017, Vol.10 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13068-017-0708-1
关键词: 13CNAD(P)HFatty acidsFlux balance analysisOne-carbon metabolic pathway
英文摘要: C1 substrates (such as formate and methanol) are promising feedstock for biochemical/biofuel production. Numerous studies have been focusing on engineering heterologous pathways to incorporate C1 substrates into biomass, while the engineered microbial hosts often demonstrate inferior fermentation performance due to substrate toxicity, metabolic burdens from engineered pathways, and poor enzyme activities. Alternatively, exploring native C1 pathways in non-model microbes could be a better solution to address these challenges.
原始语种摘要: C1 substrates (such as formate and methanol) are promising feedstock for biochemical/biofuel production. Numerous studies have been focusing on engineering heterologous pathways to incorporate C1 substrates into biomass, while the engineered microbial hosts often demonstrate inferior fermentation performance due to substrate toxicity, metabolic burdens from engineered pathways, and poor enzyme activities. Alternatively, exploring native C1 pathways in non-model microbes could be a better solution to address these challenges.
全文获取路径: Springer Nature  (合作)
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影响因子:5.552 (2012)

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关键词翻译
关键词翻译
  • microbial 微生物的
  • formate 甲酸盐
  • promising 前提
  • solution 溶液
  • microbes 微生物
  • fermentation 发酵
  • balance 平衡
  • eukaryotic 真核的
  • carbon 
  • biomass 生物量