Rituximab, methotrexate, procarbazine, vincristine and intensified cytarabine consolidation for primary central nervous system lymphoma (PCNSL) in the elderly: a LOC network study
作者: Caroline HouillierHervé GhesquièresCécile ChabrotCarole SoussainGuido AhleSylvain ChoquetEmmanuelle Nicolas-VirelizierJacques-Olivier BayJacques VargaftigClaude GaultierValérie TouitouNadine Martin-DuverneuilNathalie CassouxMagali Le Garff-TavernierMyrto CostopoulosPierre FaurieKhê Hoang-Xuan
作者单位: 1APHP, Sorbonne Universités UPMC Universités Paris VI, IHU, ICM
2Centre Léon Bérard
3CHU Estaing
4Hôpital René Huguenin-Institut Curie
5Hôpitaux Civils de Colmar
6Groupe Hospitalier Pitié-Salpêtrière
7Université Paris V
刊名: Journal of Neuro-Oncology, 2017, Vol.133 (2), pp.315-320
来源数据库: Springer Nature Journal
DOI: 10.1007/s11060-017-2435-7
关键词: Primary CNS lymphomaElderly patientsChemotherapyMethotrexateCytarabineRituximabConsolidation
英文摘要: Primary CNS lymphoma (PCNSL) is chemosensitive to high-dose methotrexate-based chemotherapy. However, responses in the elderly are short-lasting and outcome is poor. Given that radiotherapy and intensive chemotherapy expose elderly to severe toxicities, alternative consolidation approaches need to be evaluated. In this multicenter study, we retrospectively analyzed consecutive patients with newly-diagnosed PCNSL, aged >60, treated with a (R)-MPV-AAA regimen. The regimen consisted of three 28-day cycles of methotrexate (3.5 g/m2 D1, D15), procarbazine, vincristine, followed by three 28-day cycles of cytarabine consolidation (3 g/m2 D1-2). Addition of rituximab (375 mg/m2 D1) was optional. The results were compared with the historical MPV-A regimen. Ninety...
原始语种摘要: Primary CNS lymphoma (PCNSL) is chemosensitive to high-dose methotrexate-based chemotherapy. However, responses in the elderly are short-lasting and outcome is poor. Given that radiotherapy and intensive chemotherapy expose elderly to severe toxicities, alternative consolidation approaches need to be evaluated. In this multicenter study, we retrospectively analyzed consecutive patients with newly-diagnosed PCNSL, aged >60, treated with a (R)-MPV-AAA regimen. The regimen consisted of three 28-day cycles of methotrexate (3.5 g/m2 D1, D15), procarbazine, vincristine, followed by three 28-day cycles of cytarabine consolidation (3 g/m2 D1-2). Addition of rituximab (375 mg/m2 D1) was optional. The results were compared with the historical MPV-A regimen. Ninety...
全文获取路径: Springer Nature  (合作)
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影响因子:3.115 (2012)

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关键词翻译
关键词翻译
  • procarbazine 丙卡巴肼
  • methotrexate 氨甲喋呤
  • cytarabine 阿糖胞苷
  • lymphoma 淋巴瘤
  • vincristine 长春新碱
  • chemotherapy 化学疗法
  • nervous 神经的
  • intensified 修]增长[亮,强
  • thrombopenia 血小板减少
  • consolidation 固结