Impacts of TNF-LTA SNPs/Haplotypes and Lifestyle Factors on Oral Carcinoma in an Indian Population
作者: Kapil BandilPallavi SinghalUpma SharmaShowket HussainSurojit BasuAditya ParashariVeena SinghAshok SehgalAnimesh ShivamPuneet AhujaMausumi BharadwajBasu Dev BanerjeeRavi Mehrotra
作者单位: 1Institute of Cytology and Preventive Oncology (ICMR)
2Barasat Cancer Hospital
3Institute of Technology and Science
4University College of Medical Sciences, University of Delhi Dilshad Graden
刊名: Molecular Diagnosis & Therapy, 2016, Vol.20 (5), pp.469-480
来源数据库: Springer Nature Journal
DOI: 10.1007/s40291-016-0215-2
原始语种摘要: Abstract(#br) Background and Objectives(#br)To investigate a potential association between single-nucleotide polymorphisms (SNPs) and haplotypes at the TNFA-LTA locus and the development of oral cancer in an Indian population.(#br) Materials and Methods(#br)In this study, 150 oral precancer/cancer samples (50 precancer and 100 cancer), along with an equal number of control samples, were genotyped. Six SNPs at the TNF-LTA locus (i.e., −238G/A, −308G/A, −857C/T, −863C/A, −1031T/C, and +252A/G) were analyzed by use of a polymerase chain reaction–restriction fragment length polymorphism method, the assay was validated by sequencing 10 % of samples.(#br) Results(#br)The allelic frequencies of TNFA and LTA SNPs were found to be significantly associated with the risk of oral cancer and...
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影响因子:1.692 (2012)

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