Validation of a proteomic biomarker panel to diagnose minor-stroke and transient ischaemic attack: phase 2 of SpecTRA, a large scale translational study
作者: Andrew M. PennMaximilian B. BibokViera K. SalyShelagh B. CouttsMary L. LesperanceRobert F. BalshawKristine VotovaNicole S. CroteauAnurag TrivediAngela M. JacksonJanka HegedusEvgenia KlourfeldAmy Y. X. YuCharlotte ZernaJayesh ModiPhilip A. BarberGordon HoagChristoph H. Borchers
作者单位: 1Department of Neurosciences , Stroke Rapid Assessment Clinic, Island Health Authority , Victoria , Canada
2;Department of Research and Capacity Building , Island Health Authority , Victoria , Canada
3;Departments of Clinical Neurosciences, Radiology, and Community Health Services , University of Calgary , Calgary , Canada
4;Department of Mathematics and Statistics , University of Victoria , Victoria , Canada
5;George & Fay Yee Centre for Healthcare Innovation , University of Manitoba , Winnipeg , Canada
6;Division of Medical Sciences , University of Victoria , Victoria , Canada
7;Genome British Columbia Proteomics Centre, University of Victoria , Victoria , Canada
8;Department of Medicine , University of Toronto , Toronto , Canada
9;Department of Radiology , Foothills Medical Centre , Calgary , Canada
10;Department of Clinical Neurosciences , University of Calgary , Calgary , Canada
11;Department of Laboratory Medicine, Pathology & Medical Genetics , Island Health Authority , Victoria , Canada
刊名: Biomarkers, 2018, Vol.23 (8), pp.793-803
来源数据库: Taylor & Francis Journal
DOI: 10.1080/1354750X.2018.1499130
关键词: TIATransient ischaemic attackTIA biomarkersStroke biomarkersStroke proteomicPlasma biomarkers
原始语种摘要: Abstract(#br)OBJECTIVE:(#br) To validate our previously developed 16 plasma-protein biomarker panel to differentiate between transient ischaemic attack (TIA) and non-cerebrovascular emergency department (ED) patients.(#br)METHOD:(#br) Two consecutive cohorts of ED patients prospectively enrolled at two urban medical centers into the second phase of SpecTRA study (training, cohort 2A, n = 575; test, cohort 2B, n = 528). Plasma samples were analyzed using liquid chromatography/multiple reaction monitoring-mass spectrometry. Logistic regression models which fit cohort 2A were validated on cohort 2B.(#br)RESULTS:(#br) Three of the panel proteins failed quality control and were removed from the panel. During validation, panel models did not outperform a simple motor/speech (M/S) deficit...
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  • panel 
  • multivariate 多元
  • attack 侵蚀
  • variable 变量
  • exploratory 勘探的
  • discuss 议论
  • TIA Type Inspection Authorization
  • transient 瞬变现象
  • cohort 伙伴
  • monitoring 监视