Huangqi Jianzhong Tang ameliorated phospholipase A2 and glycerophospholipids metabolism against chronic atrophic gastritis rats
作者: YueTao LiuYingHuan HuGuoHong WangAiPing LiKe LiQingXia ZhengXueMei Qin
作者单位: 1Modern Research Center for Traditional Chinese Medicine of Shanxi University , Taiyuan , P. R. China
2;College of Chemistry and Chemical Engineering of Shanxi University , Taiyuan , P. R. China
3;Department of Pharmacy , Shanxi Provincial Hospital of Traditional Chinese Medicine , Taiyuan , P. R. China
4;Zhengzhou Tobacco Research Institute of CNTC , Zhengzhou , P. R. China
刊名: Journal of Liquid Chromatography & Related Technologies, 2018, Vol.41 (19-20), pp.1082-1091
来源数据库: Taylor & Francis Journal
DOI: 10.1080/10826076.2018.1562941
关键词: Huangqi Jianzhong TangChronic atrophic gastritisLC-MSPhospholipase A2Glycerophospholipids metabolism
原始语种摘要: Abstract(#br)Huangqi Jianzhong Tang (HQJZ), a famous classic traditional Chinese medicine (TCM) formula, could protect metabolic perturbations of carbohydrates and amino acids induced by chronic atrophic gastritis (CAG) in our previous metabolomic study based on nuclear magnetic resonance (NMR) technology. The present study was designed to improve the metabolome coverage to investigate the regulative mechanism of HQJZ against CAG through ultra-high-performance liquid chromatographys coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q/TOF-MS) based-metabolomic approach. The results revealed that thirteen potential biomarkers were significantly regulated by HQJZ, which were involved into bile acid biosynthesis, sphingolipid metabolism, fatty acid metabolism and...
全文获取路径: Taylor & Francis  (合作)

  • metabolism 代谢
  • gastritis 胃炎
  • atrophic 萎缩的
  • against 反对
  • phospholipase 磷脂酶
  • demonstrated 探明的储量
  • chronic 延续很长的
  • sphingolipid 鞘脂类
  • endogenous 内成的
  • medicine