Verification of a proteomic biomarker panel to diagnose minor stroke and transient ischaemic attack: phase 1 of SpecTRA, a large scale translational study
作者: Andrew M. PennMaximilian B. BibokViera K. SalyShelagh B. CouttsMary L. LesperanceRobert F. BalshawKristine VotovaNicole S. CroteauAnurag TrivediAngela M. JacksonJanka HegedusEvgenia KlourfeldAmy Y. X. YuCharlotte ZernaChristoph H. Borchers
作者单位: 1Neurosciences, Stroke Rapid Assessment Clinic , Island Health Authority , Victoria , BC , Canada
2;Department of Research and Capacity Building , Island Health Authority , Victoria , BC , Canada
3;Departments of Clinical Neurosciences, Radiology, and Community Health Services , University of Calgary, Hotchkiss Brain Institute, C1242, Foothills Medical Centre , Calgary , AB , Canada
4;Department of Mathematics and Statistics , University of Victoria , Victoria , BC , Canada
5;British Columbia Centre for Disease Control , Vancouver , BC , Canada
6;Division of Medical Sciences , University of Victoria , Victoria , BC , Canada
7;University of Victoria – Genome British Columbia Proteomics Centre, Vancouver Island Technology Park , Victoria , BC , Canada
8;Department of Medicine , University of Toronto Sunnybrook Health Sciences Centre , Toronto , ON , Canada
9;Department of Biochemistry and Microbiology , University of Victoria , Victoria , BC , Canada
10;Gerald Bronfman Department of Oncology , Jewish Gen
刊名: Biomarkers, 2018, Vol.23 (4), pp.392-405
来源数据库: Taylor & Francis Journal
DOI: 10.1080/1354750X.2018.1434681
关键词: TIATransient ischaemic attackTIA biomarkersStroke biomarkersStroke proteomicPlasma biomarkers
原始语种摘要: Abstract(#br)Objective:(#br) To derive a plasma biomarker protein panel from a list of 141 candidate proteins which can differentiate transient ischaemic attack (TIA)/minor stroke from non-cerebrovascular (mimic) conditions in emergency department (ED) settings.(#br)Design:(#br) Prospective clinical study (#NCT03050099) with up to three timed blood draws no more than 36 h following symptom onset. Plasma samples analysed by multiple reaction monitoring-mass spectrometry (MRM-MS).(#br)Participants:(#br) Totally 545 participants suspected of TIA enrolled in the EDs of two urban medical centres.(#br)Outcomes:(#br) 90-day, neurologist-adjudicated diagnosis of TIA informed by clinical and radiological investigations.(#br)Results:(#br) The final protein panel consists of 16 proteins whose...
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关键词翻译
关键词翻译
  • attack 侵蚀
  • stroke 笔划
  • transient 瞬变现象
  • TIA Type Inspection Authorization
  • protein 蛋白质
  • panel 
  • translational 平移的
  • minor 次要的
  • neurologist 神经学家
  • lactonase 内酯酶