HPV Has Left the Building—the Absence of Detectable HPV DNA and the Presence of R Allele/S for the P72R Polymorphism in the TP53 Gene May Call for More Aggressive Therapeutic Approach in HPV-Associated Tumours
作者: Rumena PetkovaPavlina ChelenkovaHusein YemendzhievIliya TsekovStoyan ChakarovZlatko Kalvatchev
作者单位: 1Scientific Technological Service (STS Ltd.) , Sofia , Bulgaria
2Burgas University ‘Prof. Dr. Asen Zlatarov’ , Burgas , Bulgaria
3Molecular Virology Laboratory, Military Medical Academy , Sofia , Bulgaria
4Sofia University “St. Kliment Ohridsky” , Sofia , Bulgaria
刊名: Biotechnology & Biotechnological Equipment, 2013, Vol.27 (6), pp.4217-4221
来源数据库: Taylor & Francis Journal
DOI: 10.5504/BBEQ.2013.0104
关键词: HPV DNACINcarcinogenesisp53P72R
原始语种摘要: ABSTRACT(#br)HPV infection is a major pathogenetic factor in cervical carcinoma as well as in many of the squamous cancers of head and neck and other epithelial cancers. Persistence of HPV DNA detectable by routine methods is considered to be a risk factor for advanced CIN and, in patients treated by surgery or non-surgical treatment modalities (radiotherapy, chemotherapy), HPV persistence is believed to be associated with increased risk for local recurrence. In terms of survival, however, it has been repeatedly proven that patients with cervical cancer and other HPV-associated cancers with detectable HPV DNA tend to have better outcomes than patients with HPV-negative tumours. The P72R polymorphism in the human TP53 gene has been contemplated as an independent phenotype modifier in...
全文获取路径: Taylor & Francis  (合作)

  • DNA Deoxyribonucleic Acid