Inhibitors of osteoblastogenesis in early human milk and maternal serum: evidence for protective properties of mother’s milk on bone
作者: Despina D. BrianaStavroula GavriliSophia GeorgantziAntonios MarmarinosKonstantinos VoulgarisChristos ChristouDimitrios GourgiotisAriadne Malamitsi-Puchner
作者单位: 1Medical School , National and Kapodistrian University of Athens , Athens , Greece
2;Neonatal Intensive Care Unit , General District Hospital "Alexandra" , Athens , Greece
3;Laboratory of Clinical Biochemistry – Molecular Diagnostics, 2nd Department of Pediatrics , National and Kapodistrian University of Athens , Athens , Greece
4;Hellenic Statistical Authority , Athens , Greece
刊名: The Journal of Maternal-Fetal & Neonatal Medicine, 2020, Vol.33 (7), pp.1095-1099
来源数据库: Taylor & Francis Journal
DOI: 10.1080/14767058.2018.1514383
关键词: Bone formationBreast milkDKK1Maternal bloodSclerostinWnt signaling pathway
原始语种摘要: Abstract(#br)Objective:(#br) Lactation is associated with a dramatic increase of maternal bone turnover, leading to a reversible bone loss. Early life nutrition may influence later osteoporosis risk. Proteins synthesized by the group of wingless (Wnt) genes are key mediators of osteoblastogenesis and bone formation. We aimed to investigate maternal milk and serum concentrations of the inhibitors of the Wnt signaling pathway, Dickkopf-1 (DKK-1) and sclerostin.(#br)Material and methods:(#br) In 80 women, maternal milk and serum concentrations of DKK-1 and sclerostin were determined by ELISA on the 3rd–4th day postpartum. Concentrations were associated with various maternal, gestational and neonatal characteristics.(#br)Results:(#br) DKK-1 and sclerostin were detectable in early milk [mean ±...
全文获取路径: Taylor & Francis  (合作)

  • 无翅的 浓聚物
  • 相关的 母亲
  • maternal 母的
  • serum 血清
  • early 
  • correlated 相关
  • concentrations 浓聚物
  • wingless 浓聚物
  • osteoporosis 骨质疏松
  • mother 母亲
  • associated 母亲
  • positively 断然