Placental leptin mRNA expression and serum leptin levels in pre-eclampsia associated with HIV infection
作者: Firoza HaffejeeThajasvarie NaickerMoganavelli SinghAyesha B. M. KharsanyMiriam AdhikariRavesh SinghNiren MaharajJagidesa Moodley
作者单位: 1Optics & Imaging Centre, University of KwaZulu-Natal , Durban , South Africa
2;Discipline of Biochemistry , School of Life Sciences, University of KwaZulu-Natal , Durban , South Africa
3;Centre for AIDS Programme Research in South Africa , Durban , South Africa
4;Department of Paediatrics and Child Health , University of KwaZulu-Natal , Durban , South Africa
5;HIV Pathogenesis Programme , University of KwaZulu-Natal , Durban , South Africa
6;Department of Obstetrics and Gynaecology , Prince Mshiyeni Memorial Hospital , Durban , South Africa
7;Woman’s Health and HIV Research Group , University of KwaZulu-Natal , Durban , South Africa
刊名: Journal of Obstetrics and Gynaecology, 2017, Vol.37 (1), pp.48-52
来源数据库: Taylor & Francis Journal
DOI: 10.1080/01443615.2016.1209170
关键词: Leptin mRNAHIVPre-eclampsia
原始语种摘要: Abstract(#br)Leptin, primarily produced by adipocytes, is implicated in the development of pre-eclampsia. This study examines placental leptin production and serum leptin levels in HIV infected and uninfected normotensive and pre-eclamptic pregnancies. Placental leptin production was analysed by RT-PCR and serum leptin levels by ELISA in normotensive ( n = 90) and pre-eclamptic ( n = 90) pregnancies which were further stratified by HIV status. Placental leptin production was higher in pre-eclampsia compared to normotensive pregnancies irrespective of HIV status ( p = .04). Serum leptin was non-significantly raised in HIV uninfected ( p = .42) but lower in HIV-infected ( p = .03) pre-eclampsia. The latter had lower BMI ( p = .007) and triceps skin-fold thickness ( p < .001) than the HIV...
全文获取路径: Taylor & Francis  (合作)
分享到:

×
关键词翻译
关键词翻译
  • eclampsia 惊厥
  • HIV Hydraulic Isolation Valve
  • serum 血清
  • normotensive 血压正常的
  • eclamptic 惊阙的
  • triceps 三头肌
  • indicative 象征
  • placental 胎盘的
  • lower 降下
  • expression 表示