Co-Expression Network Analysis Identified Genes Associated with Cancer Stem Cell Characteristics in Lung Squamous Cell Carcinoma
作者: Songbing QinXiang LongQi ZhaoWeiXin Zhao
作者单位: 1Radiation Oncology , The First Affiliated Hospital of Soochow University, Soochow University , Suzhou , Jiangsu , China
2;Department of Respiratory Disease , Peking University Shenzhen Hospital , Shenzhen , Guangdong , China
3;Department of Radiation Oncology , Fudan University Shanghai Cancer Center , Shanghai , China
4;Department of Oncology , Shanghai Medical College, Fudan University , Shanghai , China
5;Institue of Thoracic Oncology, Fudan University , Shanghai , China
刊名: Cancer Investigation, 2020, Vol.38 (1), pp.13-22
来源数据库: Taylor & Francis Journal
DOI: 10.1080/07357907.2019.1697281
关键词: LSCCMRNAsiWGCNATCGAPrognosisCancer stem cell
原始语种摘要: Abstract(#br)Objective:(#br) Cancer stem cells are self-renewal cells in tumors and can produce heterogeneous tumor cells, which play an important role in the development of lung squamous cell carcinoma (LSCC). In our research, we aimed to explore the expression of genes related to LSCC stem cells.(#br)Methods:(#br) We downloaded the RNAseq data, the pathological and prognostic profiles of LSCC cases from the public database TCGA. The mRNA expression-based stiffness index (mRNAsi) of LSCC was calculated and the prognostic value of mRNAsi was discussed. Then, we constructed a weighted gene co-expression network analysis (WGCNA) to screen key genes related to mRNAsi of LSCC.(#br)Results:(#br) MRNAsi is an independent prognostic factor in LSCC. We screened 5 key genes (BUB1, BIRC5, CCNB2,...
全文获取路径: Taylor & Francis  (合作)
影响因子:2.238 (2012)

  • expression 表示
  • screened 筛过的
  • related 有关的
  • important 重要的
  • expressed 榨出的
  • addition 添加
  • Cancer 巨蟹座
  • prognostic 预测的
  • database 资料库
  • proteins 蛋白质